期刊论文

中文

湖南中医药大学学报

1674-070X

2017

37

11

1204-1208

10.3969/j.issn.1674-070X.2017.11.009

09C733:湖南省教育厅项目 11C0956:湖南省教育厅项目 2013FJ3057:湖南省科技厅项目

本校为第一机构

目的 通过观察痛泻要方对腹泻型肠易激综合征模型血清及结肠组织中胰高血糖素样肽-1(glucagon-like PeP-tide-1,GLP-1)、胃动素(Motilin,MTL)和生长抑素(Somatostatin,SS)含量的影响,研究胰岛-肠轴调节在腹泻型肠易激综合征中的机制及干预效果.方法 将80只清洁级SD大鼠,随机分为正常空白对照组(A组),模型对照组(B组)、痛泻要方组(C组)、阳性药物对照组(D组),造模成功后分组干预,与阳性药物对照组比较,观察其对模型大鼠血清及结肠组织中GLP-1、SS及MTL的含量.结果 与空白对照组比较,模型大鼠血清及结肠中GLP-1含量降低,SS及MTL含量明显增加(P

Objective To study on the mechanism and intervention effect of islet-intestinal axis regulation in diarrhea predominant irritable bowel syndrome through observing the effect of Tongxieyaofang decoction on glucagon like peptide-1 (GLP-1), motilin (MTL) and somatostatin (SS) in diarrhea predominant irritable bowel syndrome model. Methods 80 SD rats were randomly divided into blank control group (group A), model group (group B), Tongxie Yaofang group (group C), positive control group (group D). After succesfully building models, the contents of GLP-1, SS and MTL in serum and colon of model rats w...