期刊论文

Research Progress of Related Signaling Pathways of Renal Fibrosis Syndromes Regulated by Traditional Chinese Medicine

中文

湖南中医药大学学报

1674-070X

2017

37

9

1044-1048

10.3969/j.issn.1674-070X.2017.09.029

1022-0001019:大学生创新性项目 15A144:湖南省教育厅科学研究重点项目 20134323120007:高等学校博士学科点专项科研基金

本校为第一机构

肾纤维化相关研究的信号转导通路包括TGF-β1/Smad通路、Wnt/β-catenin信号通路、m TOR信号通路、Sonic Hedgehog通路、ERK1/2通路、P38 MAPK信号通路和HGF/c-met信号通路等。大量实验研究表明,中医方药可通过多环节、多途径、多靶点调节相关信号通路的表达,干预肾纤维化进程。基于此,本文就中医药干预肾纤维化相关信号通路研究进展进行综述,以期为中医药防治肾纤维化疾病提供循证依据。

Renal fibrosis related signal transduction pathways include TGF-β 1/Smad pathway, Wnt/β-catenin signaling pathway, mTOR signaling pathways, Sonic Hedgehog pathway, ERK 1/2 pathway, P38 lightning MAPK signaling pathways and HGF/c-met signaling pathways, etc. A large number of studies showed that prescriptions of traditinal Chinese medicine could intervene the process of renal fibrosis by regulating the expression of signaling pathways through multi-link, multi-way, multi-targets. The research progress of TCM intervention in renal fibrosis rela...