期刊论文

中文

湖南中医药大学学报

1674-070X

2017

37

6

581-585

10.3969/j.issn.1674-070X.2017.06.001

81403387:国家自然科学基金 14C0862:湖南省教育厅一般项目 99820001-147:湖南中医药大学校级青年基金 ZYNK201503:教育部重点实验室开放基金

本校为第一机构

目的 研究甘麦大枣汤对慢性应激抑郁模型大鼠HPA轴及海马显微结构的影响,探讨其可能的抗抑郁机制.方法 将SD大鼠随机分为6组:空白组、模型组、氟西汀组(5.4 mg/kg)、甘麦大枣汤高、中、低剂量组(3.84、1.92、0.96 g/kg),采用慢性不可预见性温和应激建立抑郁模型,于造模同时给药,连续21 d.采用糖水消耗实验和旷场测试检测大鼠的抑郁样行为,ELISA法检测大鼠血浆促肾上腺皮质激素释放激素(CRH)、促肾上腺皮质激素(ACTH)、皮质酮(CORT)的变化,HE染色观察大鼠海马CA1区、CA3区及齿状回(DG)区的病理结构变化.结果 与空白组比较,抑郁模型组大鼠蔗糖偏食度及自主活动次数显著下降(P

Objective To study the effects of Ganmai Dazao decoction on the HPA axis and hippocampus microstructure in depressive rats induced by chronic stress, and to explore the possible mechanism of its antidepressive role. Methods SD rats were randomly divided into six groups： control group, model group, fluoxetine group （5.4 mg/kg）, high, medium and low dose of Ganmai Dazao Tang group （3.84, 1.92, 0.96 g/kg）. The model of depression was established by chronic unpre-dictable mild stress, administered simultaneously in modeling, which was administ...