期刊论文

Study on Anti-depressant Effect of Compound Chaijin Jieyu Tablet

中文

湖南中医药大学学报

1674-070X

2017

37

1

18-21

10.3969/j.issn.1674-070X.2017.01.004

国家自然科学基金青年项目（81403387）； 湖南省科技厅重点项目（2015DK3003）；

本校为第一机构

目的：初步探讨复方柴金解郁片的抗抑郁作用。方法建立两种小鼠抑郁模型，即小鼠强迫游泳实验和悬尾实验复制应激行为绝望抑郁模型，五羟色胺酸和利血平诱导药物所致抑郁模型；检测小鼠强迫游泳实验和悬尾实验不动时间，五羟色胺酸诱导的抑郁小鼠甩头次数，利血平诱导的抑郁小鼠体温、眼睑闭合、运动不能差异程度。结果小鼠强迫游泳实验和悬尾实验中，与空白对照组比较，复方柴金解郁片2倍或（1倍）剂量组不动时间明显减少（P＜0.05）。在五羟色胺酸诱导的小鼠甩头实验中，与空白对照组比较，复方柴金解郁片2倍剂量组甩头次数明显增加（P＜0.05或P＜0.01）。在利血平诱导的小鼠抑郁实验中，与空...

Objective Preliminary study on the anti-depressant effect of compound Chaijin Jieyu tablet (CJJY). Methods Two kinds of mice models of depression were established, the mice forced swimming test and hanging tail test replication stress behavioral despair models of depression, serotonin acid and reserpine induced drug-induced depression model; detection of mouse forced swimming test and the tail suspension test in the time of immobility, serotonin acid induced depression in mice the number of head twitches, reserpine induced depression of body temperature, eyelid closure, akinesi-a difference de...