Objective To prepare baicalin liposomes modified with glycyrrhetinic acid. Methods The carbenoxolone eighteen alcohol ester (18-GA-Suc)by chemical synthesis method was as amphiphilic guidance molecule. The optimal method was investigated from its stability, encapsulation efficiency. The single factor and orthogonal test was used to optimize the pre-scription and process. Results According to the optimized process, the appearance of the baicalin liposomes modified by the glycyrrhetinic acid was milky white, with pale blue light and no flocculation, and the encapsulation efficiency was for 41.75...