期刊论文

中文

湖南中医药大学学报

1674-070X

2017

37

5

473-476

10.3969/j.issn.1674-070X.2017.05.003

81303003:国家自然科学基金 81403427:国家自然科学基金 181:湖南省大学生研究性学习和创新性实验计划

本校为第一机构

目的 观察中药护卵汤对反复多周期促排卵小鼠子宫内膜容受性的干预作用,为中医药辅治体外受精-胚胎移植(IVF-ET)提供更多的实验依据.方法 建立反复多周期促排卵小鼠模型(模型组),部分给予中药护卵汤治疗(中药组),以及未使用药物的自然周期小鼠为正常对照(空白组).比较各组在孕2 d、孕5 d两个时间段的子宫形态及雌激素受体(ER)和孕激素受体(PR)的蛋白表达.结果 子宫内膜光学形态:与空白组和中药组相比,孕5 d模型组小鼠子宫内膜发育明显不良.子宫内膜ER蛋白表达:与模型组相比,孕2 d和孕5 d中药组小鼠子宫内膜ER蛋白表达均增加,差异有统计学意义(P

Objective To observe the effects of Huluan decoction on expression of ER and PR in endometrium of multi-period ovulation induction mice, and to provide more related basis for the effectiveness of Huluantang assisting in vitro fertilization and embryo transfer (IVF-ET). Methods The multi-period ovulation induction mice models were built. The Chinese medicine group was administrated with Huluan decoction, the normal group was given no drugs. The morphology of endometrium and expression of ER and PR in endometrium were observed on the 2nd day and the 5th day of pregnant (P2 and P5). Results Compa...