期刊论文

Effects of Xuefu Zhuyu Decoction on the Expression of Monocyte Chemoattractant Protein-1 in Aortic Tissue of Atherosclerosis Rabbits

中文

湖南中医药大学学报

1674-070X

2017

37

12

1312-1315

10.3969/j.issn.1674-070X.2017.12.004

国家自然科学基金面上项目（81373641）； 2012年度湖南省大学生研究性学习和创新性实验计划项目（2012181）； 2013年度湖南省中医药科研计划项目（2013161）； 2014年湖南省科学技术厅课题（2014SK3050）；

本校为第一机构

目的 观察血府逐瘀汤对动脉粥样硬化家兔主动脉组织单核细胞趋化因子-1(monocyte chemotactic protein-1,MCP-1)表达的影响,并探讨血府逐瘀汤抗动脉粥样硬化的机制.方法 将24只清洁级日本雄性大耳家兔,随机分为3组,每组8只:空白组给予普通饲料;模型组先给予高胆固醇高脂饲料100 g/d后给予普通饲料;血府逐瘀汤组在模型组喂养的基础上,灌胃给予血府逐瘀汤,每天1次.喂养8周后,采血测定家兔血脂全套(TG、TC、LDL);应用光学显微镜观察兔主动脉切片的病理改变,测定其主动脉粥样硬化斑块灰度及斑块面积;利用免疫组织化学方法测定主动脉MCP-1蛋白的表达.结果 主动脉图像分析血府逐瘀汤组家兔胸主动脉斑块...

Objective To observe the effect of Xuefu Zhuyu decoction on the expression of monocyte chemoattractant protein-1 (MCP-1) in aortic tissue of atherosclerosis rabbits. Methods Twenty-four male rabbits were randomly divided into three groups, 8 rats in each group. The control group was fed with normal diet, the model group was given with 100g/d high fat and cholesterol diet before feeding normal diet; and Xuefu Zhuyu decoction group was administrated with Xuefu Zhuyu decoction, once daily. The concentrations of serum total cholesterol (TC) , total triglyceride (TG), low density lipoprotein (LDL) ...