期刊论文

中文

湖南中医药大学学报

1674-070X

2017

37

9

943-946

10.3969/j.issn.1674-070X.2017.09.006

湖南省教育厅科学研究项目（16A158）；

本校为第一机构

目的 从肾素-血管紧张素-醛固酮系统切入,探讨心痛泰对冠心病血管重塑的调控作用.方法 将95只SD大鼠随机抽取17只为正常组,其余78只采用喂饲高脂饲料并腹腔注射垂体后叶素的方法制备冠心病大鼠模型.将造模成功的大鼠随机分为模型组,心痛泰低、中、高剂量组和卡托普利组.各组分别予相应的药物灌胃,正常组和模型组以同等体积的蒸馏水灌胃,每日1次,连续28 d.采用HE染色观察大鼠冠状动脉病理变化,ELISA法检测大鼠血浆肾素(PRA)、血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)的含量.结果 治疗4周后,与冠心病模型组比较,心痛泰低、中、高剂量组和卡托普利组心脏指数、左心室质量指数、右心室质量指数降低,冠状动...

Objective To observe the effects of Xintongtai on cardiovascular remodeling in rats with coro-nary heart disease and illustrate the therapeutic mechanisms from renin-angiotensin-aldosterone system （RAAS）. Methods 17 rats as the normal group were randomly selected from 95 SD rats, and the rest, 78 rats were used for coronary heart disease rat models which were established by high fat diets and intraperitoneal injection of Pituitrin. Then the successful model rats were randomly divided into five groups： the model group, low, middle, high dosag...