期刊论文

Effects of Compound Chaijin Jieyu Tablets on HPA Axis and Hippocampal Monoamine Neurotransmitter in Chronic Stress Depression Rats

中文

湖南中医药大学学报

1674-070X

2017

37

3

240-244

10.3969/j.issn.1674-070X.2017.03.003

国家自然科学基金项目（81573965）；

本校为第一机构

目的 研究复方柴金解郁片对慢性应激抑郁模型大鼠HPA轴及海马单胺神经递质的影响,探讨其可能的抗抑郁机制.方法 将SD大鼠随机分为6组:对照组、模型组、氟西汀组(5.4 mg/kg)、复方柴金解郁片高、中、低剂量组(2.74、1.37、0.68 g/kg),采用慢性不可预见性温和应激建立抑郁模型,于造模同时给药,连续28 d.采用蔗糖偏好实验和旷场测试检测大鼠的抑郁样行为,Morris水迷宫检测大鼠的学习记忆能力,HE染色观察大鼠海马病理结果变化,ELISA法检测大鼠血浆促肾上腺皮质激素释放激素(CRH)、促肾上腺皮质激素(ACTH)、皮质酮(CORT),以及海马5-羟色胺(5-HT)、5-羟吲哚乙酸(5-HIAA)、去甲肾上腺素(NA)、多巴胺(DA...

Objective To study the effect of compound Chaijin Jieyu tablets on HPA axis and hippocampal monoamine neurotransmitter in chronic unpredictable stress model rats, and to explore its possible antidepressant mechanism. Methods SD rats were randomly divided into six groups: the control group, model group, fluoxetine group (5.4 mg/kg), and high, medium and low dose of compound Chaijin Jieyu tablets group (2.74,1.37,0.68 g/kg). Chronic unpredictable mild stress was used to build the model of depression, and the model was administered simultaneously for 28 days. Sugar prefer-ence test and open field...