期刊论文

Study on the Essence of Syndrome and Drug Intervention in Rats with Hypertensive Heart Failure

中文

湖南中医药大学学报

1674-070X

2018

38

8

853-857

10.3969/j.issn.1674-070X.2018.08.003

国家自然科学基金项目（81373550,81503627,81774208）； 湖南省教育厅实验平台开放基金项目（2017K070）； 袁肇凯名师工作室项目；

本校为第一机构

目的 研究参附注射液和参麦注射液对高血压心力衰竭大鼠的疗效差异,通过"以方测证"理论推测高血压心衰大鼠所属中医证型.方法 将60只Dahl盐敏感性大鼠分为对照组、模型组、参附组和参麦组,每组15只,对照组使用低盐饲料,其余三组使用8％NaCl高盐饲料喂养大鼠20周并予以相应干预,检测大鼠血清氨基末端脑钠肽前体(n-terminal pro-brain natriuretic pep-tide,NT-proBNP),彩色超声多普勒检测大鼠左室射血分数(left ventricular ejection fraction,LVEF)和左室短轴缩短率(left ventricu-lar fractional shortening,LVFS)及观察HE染色心肌细胞.结果 与对照组比较,模型组LVEF和LVFS值均降低(P

Objective To investigate the traditional Chinese medicine （TCM） syndrome types in rats with hypertensive heart failure based on the theory of ＂Syndrome Differentiation Through Formula＂ by investigating the clinical efficacy of Shenfu injection versus Shenmai injection in rats with hypertensive heart failure. Methods A total of 60 Dahl salt sensitive rats were equally and randomly divided into control group, model group, Shenfu injection group （Shenfu group）, and Shenmai injection group （Shenmai group）. The control group was fed with low...