期刊论文

中文

湖南中医药大学学报

1674-070X

2018

38

10

1133-1136

10.3969/j.issn.1674-070X.2018.10.009

ZYBZH-Y-HUN-24:国家中医药管理局中医药标准化项目 BG201706:湖南省中药饮片标准化及功能工程技术研究中心开放课题

本校为第一机构

目的 对卷丹百合化学成分进行抗肿瘤活性研究.方法 采用CCK-8法对百合中分离得到的对香豆酸、没食子酸、芦丁、β-胡萝卜苷进行体外抗肺癌细胞A549、胃癌细胞SGC-7901和HGC-27活性研究.结果 对香豆酸对肺癌A549及胃癌SGC-7901细胞增殖具有较弱的抑制活性,高浓度400 μg/mL的增殖抑制率分别为30.74%和33.32%,均表现出浓度依赖性.没食子酸对胃癌HGC-27细胞增殖具有明显的抑制作用,且作用随着浓度增大而明显增强,其最高浓度100 μg/mL的抑制率高达79.90%.芦丁对肺癌A549细胞增殖具有弱抑制作用,高浓度200 μg/mL的增殖抑制率为26.84%;其对胃癌SGC-7901、HGC-27细胞也有抑制作用,高浓度200 μg/mL的...

Objective To study the antitumor activity of chemical constituents from Lilium lancifolium Thunb. Methods CCK-8 assay was used to investigate the in vitro antitumor activity of p-coumaric acid, gallic acid, rutin, and β-carotene, which were extracted from Lilium lancifolium Thunb., against the lung cancer cell A549 and the gastric cancer cells SGC-7901 and HGC-27. Results p-Coumaric acid showed a relatively weak inhibitory activity against the proliferation of lung cancer A549 cells and gastric cancer SGC-7901 cells, with inhibition rates of 3...