期刊论文

Mechanism of Action of Panax notoginseng Saponins in the Intervention of Cerebrovascular Diseases： An Analysis Based on Systems Pharmacology

中文

湖南中医药大学学报

1674-070X

2018

09

1032-1037

国家自然科学基金项目（81503385）.

本校为第一机构

目的采用系统药理学方法,研究三七总皂苷（Panax notoginseng saponins, PNS）干预脑血管疾病的分子网络机制。方法首先通过文本挖掘系统挖掘PNS关联的主要疾病,然后通过多数据库联合检索PNS主要有效成分的作用靶点和脑血管疾病相关靶点;使用Cytoscape 3.2.1软件构建有效成分-作用靶点-通路-疾病网络、作用靶点蛋白-蛋白相互作用网络以及疾病靶点蛋白-蛋白作用网络,并对两个蛋白网络进行交叉融合,筛选出核心网络,对核心网络进行进一步分析和筛选。在此基础上,利用Cytoscape的插件ClueGO对核心靶点进行生物过程和通路的富集分析,综合结果和文献检索预测作用机制。结果检索得到6种主要有效成分的预...

Objective To investigate the molecular network mechanism of Panax notoginseng saponins 0PNS） in the intervention of cerebrovascular diseases based on systems pharmacology. Methods Firstly, text mining was used to identify- the diseases associated with PNS, and then text mining and search of muhiple databases were performed to obtain 194 putative targets of 6 major effective constituents and 353 targets associated with cerebrovascular diseases. The association between putative targets and cerebral isehemia was analyzed. Cytoseape 3.2.1 was used...