期刊论文

中文

湖南中医药大学学报

1674-070X

2018

38

11

1248-1252

10.3969/j.issn.1674-070X.2018.11.006

国家自然科学基金面上项目（81173327）.

本校为第一机构

目的 观察电针急性胆囊炎 (AC) 模型豚鼠阳陵泉、足三里、上巨虚、下巨虚后对胆囊组织中高迁移率族蛋白B1 (HMGB1) 、白介素-1β (IL-1β) 及核因子-κB信使核糖核酸 (NF-κB mRNA) 表达的影响, 探究胆囊下合穴——阳陵泉是否在治疗对应腑病方面存在相对特异性.方法 72只健康豚鼠随机分为正常组、模型组、阳陵泉组、足三里组、上巨虚组、下巨虚组共6组, 每组12只, 雌雄各半.除正常组外, 其余豚鼠均手术于胆囊内注射大肠杆菌建立急性胆囊炎豚鼠模型, 造模成功并治疗5 d后, 取胆囊组织, 免疫组化方法检测胆囊高迁移率族蛋白B1 (HMGB1) 及白介素-1β (IL-1β) 的水平, RT-PCR检测NF-κB mRNA的表达...

Objective To observe the effect of electroacupuncture at Yanglingquan, Zusanli, Shangjuxu, and Xiajuxu points on the expression of high-mobility group box protein B1 (HMGB1), interleukin-1 beta (IL-1β), and nuclear factor kappa B messenger RNA (NF-κB mRNA) in the gallbladder tissue in a guinea pig model of acute cholecystitis (AC), and to explore the relative specificity of Yanglingquan, the lower He-sea point of the gallbladder, in the treatment of corresponding visceral disease.Methods Seventy-two healthy guinea pigs were randomly divided i...