期刊论文

Effects of Shuangdan Mingmu Capsule on Blood Glucose,Blood Lipid and Blood Rheology in Diabetic Retinopathy Rats

中文

湖南中医药大学学报

1674-070X

2018

38

5

489-492

10.3969/j.issn.1674-070X.2018.05.001

国家自然科学基金面上项目（81473737）； 湖南省研究生创新课题（CX2016B353）；

本校为第一机构

目的 观察双丹明目胶囊对糖尿病视网膜病变(diabetic retinopathy, DR)大鼠血糖血脂及血液流变学的影响,探讨其可能的治疗机制.方法 SD大鼠经一次性尾静脉注射STZ(50 mg/kg)诱导DR模型,随机分为模型组,双丹明目胶囊高、中、低组,导升明组,同时以正常大鼠为对照.连续干预30 d后,生化法检测大鼠血糖、血脂水平,全自动血液流变快测仪检测大鼠全血粘度(WBV)、血浆粘度(PV)、红细胞沉降率(ESR)、红细胞压积(HCT)、纤维蛋白原(FIB)等血液流变指标.结果 与正常组比较,模型组大鼠血糖、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)水平均显著升高(P

Objective To observe the effects of Shuangdan Mingmu capsule on blood glucose, blood lipid and blood rheology, and to explore its possible mechanism of treatment. Methods SD rats were injected with STZ (50 mg / kg) into the tail vein to induce diabetic model with retinopathy. The rats were randomly divided into model group, high dose, medium dose and low dose of Shuangdan Mingmu capsule groups and positive drug group, normal rats as controls. After continuous administration for 30 days, the blood glucose and blood lipid of rats were measured by biochemical method. The hemorrheological indexes ...