期刊论文

中文

湖南中医药大学学报

1674-070X

2018

38

5

499-503

10.3969/j.issn.1674-070X.2018.05.003

201438:湖南省中医药科研重点项目 2017TP1018:湖南省重点实验室建设项目 CX2014B352:创新基金 kc1704005:长沙市科技计划 :湖南省中医五官科学重点学科建设项目 :中央财政支持地方高校资助项目

本校为第一机构

目的 研究蛴螬提取物口服和滴眼两种途径对年龄相关性黄斑变性(age-related macular degeneration,AMD)模型干预机制.方法 采用光损伤方法建立干性AMD活体模型,分别予以蛴螬提取物口服和滴眼,用药4周后,观察其对各细胞层半胱氨酸天冬氨酸蛋白酶-3(cysteine aspastic acid-specific protease 3,Caspase-3)、核转录因子κB(nuclear factor-κB,NF-κB)、跨膜蛋白(Fas ligand,FasL)、肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)表达的影响.结果 与空白组比较,模型组视网膜组织中的Cas-pase-3表达明显下降,FasL、TNF-α、NF-κB表达均增强(P0.05);与模型组比较,口服组和滴眼组中Caspase-3表达...

Objective To study the interventional mechanism of oral administration and eye drops of the grub extract on the age -related macular degeneration (AMD) model. Methods A Dry AMD living model was established by light damage method. Models were given grubs extract oral administration and eye drops respectively. After 4 weeks, the expression of cysreine aspastic acid-specific protease 3 (Caspase-3), nuclear factor-κB (NF-κB), Fas ligand (FasL), tumor necrosis factor-α (TNF-α) was observed. Results Compared with the blank group, the expression o...