期刊论文

Effect of Reinforcing Kidney Medicinal Diet on CTX-ⅠIndex and Bone Morphology in Postmenopausal Osteoporosis Model Rats

中文

湖南中医药大学学报

1674-070X

2018

38

4

389-392

10.3969/j.issn.1674-070X.2018.04.006

湖南省科技厅课题（2015SK20168）； 湖南中医药大学2017年一方研究生科研创新项目（YF201712）；

本校为第一机构

目的 观察补肾药膳方对绝经后骨质疏松症(PMOP)模型大鼠Ⅰ型胶原C端肽(CTX-Ⅰ)指标及骨组织形态的影响.方法 SPF级雌性SD大鼠随机分为正常组、假手术组、模型组、补肾药膳方高剂量组、补肾药膳方低剂量组、骨疏康组,每组10只.除正常组、假手术组外,其他组大鼠进行双侧卵巢摘除,适应性饲养15 d后,分组干预12周,ELISA法检测血清中骨代谢标志物CTX-Ⅰ浓度表达情况,HE染色镜下观察骨组织形态.结果 与正常组和假手术组比较,模型组、补肾药膳方高、低剂量组、骨疏康组大鼠血清CTX-Ⅰ浓度均升高(P

Objective To observe the effect of reinforcing kidney medicinal diet on CTX-Ⅰindex and bone morphological changes in postmenopausal osteoporosis (PMOP) model rats. Methods SPF female SD rats were randomly divided into normal group, sham operation group, model blank group, high dose group, low dose group and Gushukang group, with 10 rats in each group. Except normal group and sham operation group, other rats were ovariectomized. After 15 days of adaptive feeding, the rats were given intervention treatment for 12 weeks. The expression of CTX-Ⅰ ...