期刊论文

Effect of Herbal Cake-Separated Moxibustion on the Expression of Serum TNF-α and INF-γ in Rabbits with Hyperlipidemia and Atherosclerosis

中文

湖南中医药大学学报

1674-070X

2018

11

1258-1261

国家自然科学基金项目（81273828;81273830;81704182）； 湖南省自然科学基金项目（2018JJ3397）；

本校为第一机构

目的观察隔药饼灸对高脂血症合并动脉粥样硬化兔血清中肿瘤坏死因子α（TNF-α）、干扰素γ（INF-γ）含量的影响,探讨其抗动脉粥样硬化作用的机制。方法 40只新西兰大耳白兔随机分为5组,每组8只,即正常组、模型组、隔药饼灸组、直接灸组、辛伐他汀组。通过高脂饲料喂养建立高脂血症合并动脉粥样硬化兔模型,待造模成功后,除正常组外,其余四组均予以相应干预,每天1次,连续干预4周后,采用酶联免疫吸附法（ELISA）测定兔血清中TNF-a、IFN-γ。结果与正常组比较,模型组、直接灸组、辛伐他汀组血清TNF-α、IFNγ的含量升高,且差异具有统计学意义（P

Objective To observe the efleet of herbal cake-separated moxibustion on the expression of tumor necrosis factor alpha （TNF-α and interferon ganmm （INF-γ） in the sermn of rabbits with hyperlipidemia and atheroselerosis, and to investigate the meehanisnl of its anti-atheroselerotie effeet, Methods A total of 40 New Zealand white rabbits were randomly divided into five groups, namely blank control group （normal group）, model group, herbal cake - separated moxibustion group, direct moxibustion group, and simvastatin group, with eight rabbits...