期刊论文

Effect of Acupuncture at Acupoints of Dazhui, Baihui, and Renzhong on the Expression of p-VEGF Protein in Brain Tissue of Rats with Cerebral Ischemia-Reperfusion Injury

中文

湖南中医药大学学报

1674-070X

2018

38

11

1262-1266

10.3969/j.issn.1674-070X.2018.11.009

81303051:国家自然科学基金 81874508:国家自然科学基金 2016JJ3101:湖南省自然科学基金

本校为第一机构

目的 观察针刺大椎、百会、人中穴对脑缺血再灌注损伤大鼠脑组织p-VEGF蛋白表达的影响, 探讨针刺对脑缺血再灌注损伤的部分作用机制.方法 从60只大鼠中随机选择24只, 再将之随机分成正常组和假手术组, 12只/组, 其余36只大鼠参照Zea Longa线栓法制备大脑中动脉栓塞模型, 造模成功后再随机分为模型组、针刺组、依达拉奉组, 12只/组.造模大鼠生命体征平稳后, 正常组、假手术组及模型组大鼠只捆绑不针刺;针刺组大鼠针刺大椎、百会、人中三穴, 留针30 min;依达拉奉组大鼠按3 mg/kg (稀释至1mL) 腹腔注射依达拉奉, 均为每12小时1次;首次治疗前及末次治疗后, 对大鼠进行神经功能缺损评分;6次治疗完成后...

Objective To observe the effect of acupuncture at acupoints of Dazhui, Baihui, and Renzhong on the expression of plasma vascular endothelial growth factor (p-VEGF) protein in the brain tissue of rats with cerebral ischemiareperfusion injury, and to explore the partial mechanism of action of acupuncture in cerebral ischemia reperfusion. Methods A total of 60 rats were included in the study, among which 24 rats were randomly selected and divided into normal group and sham-operation group, with 12 rats per group; the remaining 36 rats were first p...