期刊论文

中文

湖南中医药大学学报

1674-070X

2018

38

11

1267-1272

10.3969/j.issn.1674-070X.2018.11.010

16B197:湖南省教育厅优秀青年项目 CX2017B453:湖南省研究生创新项目 2018JJ3384:湖南省自然基金项目

本校为第一机构

目的 观察穴位埋线疗法对缺血性认知障碍模型大鼠学习记忆力及海马CA1区形态学超微结构的影响, 并探讨其作用机制.方法 将32只SPF级雄性SD大鼠, 随机分为假手术组、模型组、穴位埋线组、药物组, 每组8只, 采用双侧颈总动脉永久性结扎法复制慢性缺血性认知障碍模型.穴位埋线组取"百会""大椎""肾俞""悬钟", 每周1次, 共埋线4次;药物组予以单唾液酸四已糖神经节苷脂钠注射液腹腔注射 (0.33 mg/kg), 每天1次, 共4周.采用Morris水迷宫测大鼠学习记忆能力, 尼氏染色法观察海马组织内尼氏小体病理变化及染色面积, 透射电镜观察大鼠海马CA1区超微结构变化.结果 与假手术组比较, 模型组大鼠学习记忆能力明...

Objective To investigate the effect of acupoint catgut embedding therapy on learning, memory, and the morphology and ultrastructure of hippocampal CA1 region in rats with ischemic cognitive impairment, and to explore its therapeutic mechanism.Methods A total of 32 male specific pathogen-free Sprague-Dawley rats were randomly and equally divided into sham-operation group, model group, acupoint catgut embedding group, and medication group. A rat model of chronic ischemic cognitive impairment was established by permanent ligation of both common ca...