期刊论文

Protective Effects of Jiawei Shengmai Buxin Dan (BXD) on Myocardial Injury in Type 2 Diabetic Rats

中文

湖南中医药大学学报

1674-070X

2019

39

4

453-458

10.3969/j.issn.1674-070X.2019.04.005

国家自然科学基金面上项目(81373551) 中医诊断学国家重点学科开放基金(2015ZYZD03) 湖南省研究生创新课题(CX2017B428,CX2018B465).

本校为第一机构

目的 探讨加味生脉补心丹(以下简称BXD)对自发性非肥胖2型糖尿病Goto-kakisaki(GK)大鼠心肌损伤的保护作用.方法 8～9周龄雄性Wistar大鼠8只作为空白组,另将40只糖尿病模型GK大鼠按随机数字表将大鼠分为5组,分别为:模型组、西药组(格列齐特缓释片组)、BXD低剂量组、BXD中剂量组、BXD高剂量组.各组大鼠按治疗方法给药10周后处死,腹主动脉采血检测空腹血糖(FPG)、糖化血红蛋白(HbAlc)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA),取左心室行心肌组织HE染色、PAS染色观察病理改变,免疫组化测定心肌凋亡相关蛋白Bax、Bcl-2的表达.结果 与空白组比较,模型组FPG、HbAlc显著升高(P...

Objective To investigate the protective effects of Jiawei Shengmai Buxin Dan (BXD) on myocardial injury in spontaneous non-obese type 2 diabetes Goto-kakisaki (GK) rats. Methods Eight male Wistar rats aged 8-9 weeks were used as a blank group. 40 diabetic GK rats were randomly divided into 5 groups:the model group, the Western medicine group (Gliclazide Sustained-release Tablets), BXD low dose group, BXD medium dose group, BXD high dose group. The rats in each group were sacrificed 10 weeks after treatment, and abdominal aortic blood sampling was used to detect fasting blood glucose (FPG), gly...