期刊论文

Effects of Acupuncture Dazhui (DU14),Baihui (GV20),Renzhong (GV26) on ES Protein Expression after Cerebral Ischemia Reperfusion Injury in Rats

中文

湖南中医药大学学报

1674-070X

2019

39

4

507-510

10.3969/j.issn.1674-070X.2019.04.015

81303051:国家自然科学基金 81874508:国家自然科学基金 2017-8397:大学生创新创业训练计划项目

本校为第一机构

目的 探讨针刺大椎、百会、人中穴对内皮抑素(Endostatin,ES)作用于大鼠脑缺血再灌注损伤后的表达变化及影响,研究ES作用于脑保护的部分机制.方法 将50只SD大鼠随机分为正常组、假手术组各10只,其余30只大鼠参照ZeaLonga线拴法制作大脑中动脉缺血模型,造模成功后再随机分为模型组、依达拉奉组、针刺组,10只/组.正常组、假手术组、模型组仅捆绑,依达拉奉组以3 mg/kg(稀释至1 mL)腹腔注射,针刺组行大椎、人中、百会穴针刺,每12 h行1次治疗,6次后行神经功能缺损评分,再行Western Blot法检测ES表达.结果 (1)神经功能缺损评分对比:治疗后,与正常组、假手术组比较,其余3组评分较高(P

Objective To investigate the changes and effects of acupuncture Dazhui (DU14), Baihui (GV20), Renzhong (GV26) on the expression of Endostatin (ES) after cerebral ischemia reperfusion injury in rats and the mechanism of ES on brain protection. Methods A total of 50 SD rats were randomly divided into the normal group and the sham operation group, with 10 rats in each group. The other 30 rats were used to establish cerebral ischemia model according to the ZeaLonga method. After successful modeling, they were divided into the model group, the edaravone group, and the acupuncture group, with 10 rat...