期刊论文

中文

湖南中医药大学学报

1674-070X

2019

39

2

184-189

10.3969/j.issn.1674-070X.2019.02.008

国家自然科学基金项目(81503492,81473617) 湖南省自然科学基金项目(2015JJ6079) 湖南省教育厅教改项目(湘教通〔2016〕400-321) 湖南中医药大学教改项目(2018-JG021)。

本校为第一机构

目的研究附子-甘草合煎液和混合液对离体蛙心的影响及其物质基础。方法通过离体蛙心实验观察附子-甘草合煎液和混合液对离体正常蛙心和心衰蛙心功能的影响,应用高效液相色谱法建立并测定附子-甘草煎液的HPLC指纹图谱。结果附子-甘草合煎液与混合液的强心作用有差别;附子与甘草配伍后其指标成分的含量发生了明显变化,且合煎液与混合液的成分变化差别显著。结论附子-甘草合煎液和混合液对离体蛙心的作用及其指纹图谱均不一致。

Objective To explore the effects of aconite-licorice combined decoction and aconite-licorice mixed liquid on the isolated frog heart and their material basis.Methods The effects of aconite-licorice combined decoction and aconite-licorice mixed liquid on the isolated normal and failing frog hearts were evaluated by isolated frog heart experiment.Their HPLC fingerprints were established and compared.Results There was a difference in the cardiotonic effect between aconite-licorice combined decoction and aconite-licorice mixed liquid.The content of index components changed significantly after the ...