期刊论文

The Research Progress of the Mechanism of Traditional Chinese Medicine in the Treatment of Hepatic Failure

中文

湖南中医药大学学报

1674-070X

2020

40

2

251-255

10.3969/j.issn.1674-070X.2020.02.027

81560752:国家自然科学基金 2018JJA140362:广西自然科学基金 2018JJA140500:广西自然科学基金 AD17129001:广西壮族自治区科技计划 GZZC16-17:广西中医药局项目

本校为第一机构

肝衰竭是各类肝脏疾病进展的终末结局,致死率高。近年来研究发现,中药可通过抑制Fas/FasL结合、抑制NF-κB和Caspase途径、抗氧化应激来抑制肝细胞凋亡,通过调节Th17/Treg平衡、CTL/Treg平衡和下调HMGB1表达来增强机体免疫功能,以及通过清除LPS、减少细胞因子释放、改善肠道菌群和内毒素血症等方式拮抗肝衰竭,提升患者的生存率。本文对中药抑制肝衰竭的多机制和多层面进行综述,为肝衰竭的治疗提供新思路。

Liver failure is the final outcome of the progression of various liver diseases with a high mortality rate.In recent years,it has been found that traditional Chinese medicine can inhibit Fas/FasL binding,NF-κB pathway,Caspase pathway,antioxidative stress to inhibit hepatocyte apoptosis.By regulating Th17/Treg balance,CTL/Treg balance,and down-regulating HMGB1 expression to enhance immune function,clearing LPS,reducing cytokine release,improving intestinal flora and endotoxemia,liver failure was antagonized and patient survival was improved.Thi...