期刊论文

Effects of Electroacupuncture on Urodynamics and MLCK,MLC,p-MLC in Detrusor Tissue of Neurogenic Bladder Rats with Complete Sacral Cord Injury

中文

湖南中医药大学学报

1674-070X

2020

40

6

727-731

10.3969/j.issn.1674-070X.2020.06.017

国家自然科学基金面上基金项目(81874510) 湖南省教育厅科学研究项目-创新平台开放基金项目(17K071)。

本校为第一机构

目的通过观察电针"次髎""三阴交""中极"穴对完全性骶髓损伤神经源性膀胱（neurogenic bladder, NB）模型大鼠尿流动力学及逼尿肌组织中肌球蛋白轻链激酶（myosin light chain kinase, MLCK）、肌球蛋白轻链（myosin light chain, MLC）和磷酸化肌球蛋白（phosphorylated myosin, p-MLC）表达的影响,探究电针治疗完全性骶髓损伤后NB的可能机制。方法 48只健康雌性SD大鼠随机分为两组,一组随机分为空白组和假手术组各12只,剩余大鼠采用改良Hassan Shaker脊髓横断法制成骶髓损伤NB大鼠模型,成模后随机分为模型组和电针组各12只,电针组大鼠术后第20天取双侧"次髎""三阴交"及"中极"进行电针干预,连续...

Objective To explore the possible mechanisms of electroacupuncture in treating neurogenic bladder after complete sacral cord injury by observing the effects of electroacupuncture at Ciliao(BL32), Sanyinjiao(SP6), Zhongji(RN3) acupoints on urodynamics and myosin light chain kinase(MLCK), myosin light chain(MLC), phosphorylated myosin(p-MLC) in detrusor tissue of the rats with neurogenic bladder(NB) after complete sacral cord injury. Methods A total of 48 healthy Sprague-Dawley female rats were randomly divided into 2 groups. One group was randomly divided a blank group and a sham operation grou...