期刊论文

Modeling the small animal with HFpEF based on etiological characteristics of Chinese and western medicine

中文

湖南中医药大学学报

1674-070X

2023

43

03

391-399

10.3969/j.issn.1674-070X.2023.03.005

82274412:国家自然科学基金 81774208:国家自然科学基金 2020JJ4062:湖南省自然科学基金项目 2020JJ5408:湖南省自然科学基金项目

本校为第一机构

射血分数保留性心力衰竭（heart failure with preserved ejection fraction, HFpEF）的发病率逐年上升，成为心力衰竭的主要患病形式，但其病理机制尚未明确，目前缺乏有效治疗方案。通过合理模拟临床病因，以复制出稳定可靠的HFpEF病证一体化模型，是开展HFpEF中西医基础研究的前提。基于HFpEF的中西医病因病机特点，概述现有HFpEF及其中医证候模型的建立方法，探讨不同方法的优势与局限，阐明发展思路。HFpEF建立方法主要涉及主动脉缩窄或高血压引发的心室压力超负荷、心肌缺血损伤、糖尿病心肌损伤等。其中，主动脉缩窄所致的压力超负荷模型为优先选择，但存在每类模型仅反映HFpEF部分特征或...

The incidence of heart failure with preserved ejection fraction(HFpEF) is increasing year by year and HFpEF has become the main form of heart failure. However, its pathological mechanism remains unclear, and there is no effective treatment scheme at present. It is the p...MORE The incidence of heart failure with preserved ejection fraction(HFpEF) is increasing year by year and HFpEF has become the main form of heart failure. However, its pathological mechanism remains unclear, and there is no effective treatment scheme at present. It is the premise of basic studies on HFpEF in Chinese and west...