期刊论文

中文

湖南中医药大学学报

1674-070X

2023

43

12

2150-2156

10.3969/j.issn.1674-070X.2023.12.002

81973920:国家自然科学基金 E2022007:湖南省中医药科研计划重点项目 22A0260:湖南省教育厅科学研究重点项目 2022CX62:湖南中医药大学研究生科研创新项目 CX20220821:湖南省研究生科研创新项目 kzd22005:长沙市指导性科技计划项目

本校为第一机构

目的 探讨壮骨止痛胶囊（Zhuanggu Zhitong Capsule, ZGZTC）对去卵巢（ovariectomised, OVX）所致骨质疏松症（osteoporosis, OP）大鼠肠道菌群的影响。方法 选用雌性SD大鼠，随机分为假手术（SHAM）组10只、造模组30只。造模组切除双侧卵巢，SHAM组仅切除卵巢周围等质量脂肪组织。1周后，将造模组随机分为OVX组、戊酸雌二醇（estradiol valerate, EV）组和ZGZTC组，每组10只。EV组灌服EV混悬液[0.09 mg/（kg·d）],ZGZTC组灌服ZGZTC混悬液[1.944 g/（kg·d）],SHAM组、OVX组灌服等体积生理盐水，给药12周后取材。HE染色观察股骨、结肠结构变化，RT-PCR法分析结肠闭合小环蛋白-1（zonula occlu...

Objective To investigate the effects of Zhuanggu Zhitong Capsule(ZGZTC)on the intestinal flora of rats with ovariectomized(OVX)-induced osteoporosis(OP).Methods Female SD rats were selected and randomized into ten in the sham-operated(SHAM)group and 30 in the modeling group.In the modeling group,both ovaries were excised,and in the SHAM group,only an equal mass of adipose tissue around the ovaries was excised.One week later,the modeling group was randomized into the OVX group,the estradiol valerate(EV)group,and the ZGZTC group,with ten rats in ...