期刊论文

中文

湖南中医药大学学报

1674-070X

2023

43

05

830-837

10.3969/j.issn.1674-070X.2023.05.011

81573621:国家自然科学基金 2021RC4064:湖南省科技创新计划 2022CX70:湖南中医药大学研究生创新课题

本校为第一机构

目的 优选甘草次酸修饰的莪术醇-芍药苷共载纳米脂质体（GA-Cur-PF-Lips）的制备工艺，并对其理化性质进行表征。方法 采用乙醇注入法制备GA-Cur-PF-Lips，通过单因素考察和Box-Behnken响应面优化法优选其制备工艺；利用透射电镜观察其显微形态，采用马尔文激光粒径仪测定其粒径、多分散指数（polydispersity index, PDI）及Zeta电位，并对其体外释放度、溶血性进行考察。结果 最佳工艺:脂质量85.19 mg，胆脂比1∶9.74，总投药量4.5 mg，导脂比1∶40，超声时间6.4 min（工作2 s、停2 s）。制得的GA-Cur-PF-Lips外观澄清并伴有淡蓝色乳光，透射电镜下观察呈类球形；其平均粒径为（101.1±0.25） ...

Objective To optimize the preparation process of curcumol and paeoniflorin co-loaded nanoliposomes(GA-Cur-PF-Lips)modified with glycyrrhetinic acid,and to characterize the physicochemical properties.Methods GA-Cur-PF-Lips were prepared by ethanol injection,and the prepa...MORE Objective To optimize the preparation process of curcumol and paeoniflorin co-loaded nanoliposomes(GA-Cur-PF-Lips)modified with glycyrrhetinic acid,and to characterize the physicochemical properties.Methods GA-Cur-PF-Lips were prepared by ethanol injection,and the prepara...