期刊论文

Exploring the mechanism of action for Yangxin Tongmai Formula in regulating rats with chronic heart failure of blood stasis pattern based on TGF-β/Smads signaling pathway

中文

湖南中医药大学学报

1674-070X

2023

43

08

1353-1360

10.3969/j.issn.1674-070X.2023.08.003

81874375:国家自然科学基金 2020JJ4464:湖南省自然科学基金项目 2021024:湖南省中医药科研计划重点项目 2022CX57:湖南中医药大学研究生创新课题

本校为第一机构

目的基于转化生长因子-β(tansforming growth factor-β,TGF-β)/Smads信号通路探讨养心通脉方对慢性心力衰竭(chronic heart failure,CHF)血瘀证大鼠心肌纤维化和炎...展开更多 目的基于转化生长因子-β(tansforming growth factor-β,TGF-β)/Smads信号通路探讨养心通脉方对慢性心力衰竭(chronic heart failure,CHF)血瘀证大鼠心肌纤维化和炎症损伤的影响。方法通过随机数字表法将45只SD雄性大鼠分为造模组(27只)、正常组(12只)和假手术组(6只),适应性喂养1周后行冠脉结扎术造模,术后10 min行心电图检测,6周后检测超声心动图、血清N端前脑钠肽(N-terminal pro-brain natriuretic peptide,NT-...

Objective To observe the effects of Yangxin Tongmai Formula(YXTMF)on myocardial fibrosis and inflammatory injury in rats with chronic heart failure(CHF)of blood stasis pattern based on the transforming growth factor-β(TGF-β)/Smads signaling pathway.Methods A total of 45...MORE Objective To observe the effects of Yangxin Tongmai Formula(YXTMF)on myocardial fibrosis and inflammatory injury in rats with chronic heart failure(CHF)of blood stasis pattern based on the transforming growth factor-β(TGF-β)/Smads signaling pathway.Methods A total of ...