期刊论文

Effects of Bushen Huoxue Decoction on skeletal,vascular,and renal functions in postmenopausal osteoporosis rats based on protein expressions of Klotho,PI3K,and Akt

中文

湖南中医药大学学报

1674-070X

2024

44

1

9-15

10.3969/j.issn.1674-070X.2024.01.002

2021ZYX07:湖南中医药大学中医学双一流课题 2021SK51008:湖南省科技创新计划项目 B2023100:湖南省中医药科研计划项目

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目的通过观察补肾活血汤对去势大鼠股骨近端、主动脉外膜及肾小管中可罗索(Klotho)蛋白,大鼠股骨近端磷脂酰肌醇3-激酶(phosphatidylinositol 3-kinase,PI3K)蛋白及蛋白激酶B(prote...展开更多 目的通过观察补肾活血汤对去势大鼠股骨近端、主动脉外膜及肾小管中可罗索(Klotho)蛋白,大鼠股骨近端磷脂酰肌醇3-激酶(phosphatidylinositol 3-kinase,PI3K)蛋白及蛋白激酶B(protein kinase B,Akt)表达水平的影响,探讨补肾活血汤治疗绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)的作用机制。方法选取6月龄SD雌性大鼠31只,第1次随机分为空白组8只、假手术组5只、手术组18只,手术造模8周后随机处...

Objective To observe the effects of Bushen Huoxue Decoction(BSHXD)on the protein expression level of Klotho in the proximal femur,adventitia of aorta,and renal tubules as well as those of phosphatidylinositol 3-kinase(PI3K)and protein kinase B(Akt)in the proximal femur ...MORE Objective To observe the effects of Bushen Huoxue Decoction(BSHXD)on the protein expression level of Klotho in the proximal femur,adventitia of aorta,and renal tubules as well as those of phosphatidylinositol 3-kinase(PI3K)and protein kinase B(Akt)in the proximal femur of ovariectomized rats,so as to explore the mechanis...