期刊论文

中文

湖南中医药大学学报

1674-070X

2024

44

02

227-234

10.3969/j.issn.1674-070X.2024.02.008

2021SK4023:湖南省临床医学研究中心(基地)项目 2023JJ40487:湖南省自然科学基金项目 2022M721127:中国博士后科学基金 2022CX29:湖南中医药大学研究生创新课题项目

本校为第一机构

目的 基于表皮生长因子受体（epidermal growth factior receptor, EGFR）/丝裂原活化蛋白激酶（mitogen-activated protein kinase, MAPK）/细胞外信号调节激酶（extracellular signal-regulated kinase, ERK）信号通路探究鳖甲煎丸对MHCC-97H肝癌细胞皮下瘤的抑瘤作用及作用机制。方法 选取30只雄性BLAB/c裸鼠，建立MHCC-97H肝癌细胞皮下瘤模型。造模成功后随机分为模型组，鳖甲煎丸低、中、高剂量组（0.55、1.1、2.2 g/kg），西药组（乐伐替尼4 mg/kg+吉非替尼80 mg/kg），每组6只。鳖甲煎丸低、中、高剂量组灌胃2次/d，西药组每周灌胃5 d，模型组予以等量生理盐水2次/d灌胃，每组连续干预2周...

Objective To investigate the inhibitory effects and their mechanism of Biejiajian Pill(BJJP)on the subcutaneous tumor of MHCC-97H hepatoma cells based on the signaling pathway of epidermal growth factor receptor(EGFR)/mitogen-activated protein kinase(MAPK)/extracellular signal-regulated kinase(ERK).Methods A total of 30 male BLAB/c nude mice were used to establish a subcutaneous tumor model of MHCC-97H hepatoma cells.After successful modeling,they were randomized into model group,low-,medium-,and high-dose BJJP groups,and western medicine group...