期刊论文

Chen, Nai-hong

英文

Brain Research Bulletin

0361-9230

2019

146

12-21

10.1016/j.brainresbull.2018.11.017

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81730096, U1402221, 81573640, 81573636, 81603315, 81373551]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7161011]; Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study [BZ0150]; CAMS Innovation Fund for Medical Sciences (CIFMS) [2016-I2M-1-004]; Scientific Research Foundation of the Higher Education Institutions of Hunan Province [15K091]; Open Program of Key Laboratory of Neurodegenerative Diseases of Ministry of Education (Capital Medical University) [2016SJBX03]; State Key Laboratory Fund Open Project [GTZK201610]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2013M540066]

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Fractalkine (CX3C chemokine ligand 1, CX3CL1) is an essential chemokine, for regulating adhesion and chemotaxis through binding to CX3CR1, which plays a critical role in the crosstalk between glial cells and neurons by direct or indirect ways in the central nervous system (CNS). Fractalkine/CX3CR1 axis regulates microglial activation and function, neuronal survival and synaptic function by controlling the release of inflammatory cytokines and synaptic plasticity in the course of the neurological disease. The multiple functions of fractalkine/CX3CR1 make it exert neuroprotective or neurotoxic e...