Activity-guided isolation of NF-κB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller

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成果类型：

期刊论文

作者：

Xie, Lian-Wu;Atanasov, Atanas G.;Guo, De-An;Malainer, Clemens;Zhang, Jing-Xian;...

通讯作者：

Kopp, Brigitte

作者机构：

[Xie, Lian-Wu] Cent South Univ Forestry & Technol, Sch Sci, Changsha 410004, Hunan, Peoples R China.

[Dirsch, Verena M.; Heiss, Elke H.; Xie, Lian-Wu; Atanasov, Atanas G.; Kopp, Brigitte; Malainer, Clemens; Zehl, Martin] Univ Vienna, Dept Pharmacognosy, A-1090 Vienna, Austria.

[Guo, De-An; Zhang, Jing-Xian; Guan, Shu-Hong] Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Natl Engn Lab TCM Standardizat Technol, Shanghai 201203, Peoples R China.

[Urban, Ernst] Univ Vienna, Dept Med Chem, A-1090 Vienna, Austria.

[Xie, Lian-Wu] Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Kopp, Brigitte] U

Univ Vienna, Dept Pharmacognosy, Althanstr 14, A-1090 Vienna, Austria.

语种：

英文

关键词：

CHEMBL2337115 (PubChem CID: 71719510);CHEMBL2337117 (PubChem CID: 71524310);CHEMBL2337118 (PubChem CID: 71524309);CHEMBL2337119 (PubChem CID: 71524308);CHEMBL2337120 (PubChem CID: 71524307);Dihydro-N-caffeoyltyramine (PubChem CID: 16119668);Fatty acids;Lycii Radicis Cortex;Lycium chinense Miller;NF-kappaB;PPARgamma;Phenolic amides;Trans-N-(p-coumaroyl)tyramine (PubChem CID: 5372945);Trans-N-caffeoyltyramine (PubChem CID: 9994897);Trans-N-feruloyltyramine (PubChem CID: 5280537)

期刊：

Journal of Ethnopharmacology

ISSN：

0378-8741

年：

2014

卷：

152

期：

页码：

470-477

DOI：

10.1016/j.jep.2014.01.029

基金类别：

Sino-Austria Project (China-TCM-Cluster Project) [PP06]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2013M531787]; Planned Science and Technology Project of Hunan Province, China [2013RS4035]; Austrian Science Fund (FWF): (NFN Drugs from Nature Targeting Inflammation (DNTI))Austrian Science Fund (FWF) [S10704]

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本校为其他机构

摘要：

Ethnopharmacological relevance: The root bark of Lycium chinense Miller, Lycii Radicis Cortex, has been used in traditional Chinese medicine (TCM) to treat different inflammation-related symptoms, such as diabetes mellitus. The pro-inflammatory transcription factor nuclear factor kappa B (NF-kappa B) is a key regulator of inflammation, while the transcription factor peroxisome proliferator-activated receptor gamma (PPAR gamma) is. a key modulator of genes involved in diabetes development. To identify putative active compound(s) from Lycii Radicis Cortex inhibiting NF-kappa B or activating PPAR...

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Activity-guided isolation of NF-κB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller

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