Advances in Ferroptosis-Inducing Agents by Targeted Delivery System in Cancer Therapy

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成果类型：

期刊论文

作者：

Xiang, Debiao;Zhou, Lili;Yang, Rui;Yuan, Fang;Xu, Yilin;...

通讯作者：

Li, X

作者机构：

[Yang, Yuan; Yuan, Fang; Yang, Rui; Xiang, Debiao; Li, Xin; Qiao, Yong] Third Hosp Changsha, Dept Pharm, Changsha, Hunan, Peoples R China.

[Yuan, Fang; Xiang, Debiao; Li, Xin; Qiao, Yong] Hunan Prov Key Lab Antiresistance Microbial Drugs, Changsha, Hunan, Peoples R China.

[Yuan, Fang; Xiang, Debiao; Li, Xin; Qiao, Yong] Clin Applicat Res Inst Antibiot Changsha, Changsha, Hunan, Peoples R China.

[Zhou, Lili; Xu, Yilin; Yang, Yuan; Yang, Rui] Hunan Univ Chinese Med, Coll Pharm, Changsha, Hunan, Peoples R China.

[Li, Xin] 176 Laodong West Rd, Changsha, Hunan, Peoples R China.

通讯机构：

[Li, X ] 1

176 Laodong West Rd, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

cancers;ferroptosis;nano-drug delivery system;target

期刊：

INTERNATIONAL JOURNAL OF NANOMEDICINE

ISSN：

1178-2013

年：

2024

卷：

页码：

2091-2112

DOI：

10.2147/IJN.S448715

基金类别：

Changsha Anti -Infective Drugs Engineering Technology Research Center [kq1801120]; Changsha Municipal Natural Science Foundation [kq2208463, kq2208464]; Hunan Provincial Science and Technology Department Foundation, China [2016SK4008, 2020SK52901]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Currently, cancer remains one of the most significant threats to human health. Treatment of most cancers remains challenging, despite the implementation of diverse therapies in clinical practice. In recent years, research on the mechanism of ferroptosis has presented novel perspectives for cancer treatment. Ferroptosis is a regulated cell death process caused by lipid peroxidation of membrane unsaturated fatty acids catalyzed by iron ions. The rapid development of bio-nanotechnology has generated considerable interest in exploiting iron-induced cell death as a new therapeutic target against ca...

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