Static pressure accelerates ox-LDL-induced cholesterol accumulation via SREBP-1-mediated caveolin-1 downregulation in cultured vascular smooth muscle cells

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成果类型：

期刊论文

作者：

Luo, Di-xian;Xia, Cheng-lai;Li, Jun-mu;Xiong, Yan;Yuan, Hao-yu;...

通讯作者：

Liao, Duan-fang

作者机构：

[Xiong, Yan; Luo, Di-xian] Cent S Univ, Sch Pharmaceut, Dept Pharmacol, Changsha 410083, Hunan, Peoples R China.

[Luo, Di-xian] First Peoples Hosp Chenzhou City, Chenzhou 423000, Hunan, Peoples R China.

[Xia, Cheng-lai] Third Affiliated Hosp Med Coll Guangzhou, Dept Pharm, Guangzhou 510150, Guangdong, Peoples R China.

[Yuan, Hao-yu] Lusong Ctr Dis Control & Prevent, Zhuzhou 412000, Hunan, Peoples R China.

[Liao, Duan-fang; Zeng, Yixin; Yuan, Hao-yu; Luo, Di-xian; Li, Jun-mu; Xia, Cheng-lai; Tang, Zhen-Wang] Univ S China, Coll Sci & Technol, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Liao, Duan-fang] H

Hunan Univ Chinese Med, Dept Tradit Chinese Diagnost, Sch Pharm, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Static pressure;Vascular smooth muscle cell;Caveolin-1;SREBP-1;Cholesterol accumulation

期刊：

Biochemical and Biophysical Research Communications

ISSN：

0006-291X

年：

2010

卷：

403

期：

页码：

52-58

DOI：

10.1016/j.bbrc.2010.10.111

基金类别：

This work was supported by the National Natural Science Foundation of China ( 30770868 , 30971170 ), the Natural Science Foundation of Hunan Province, China (No. 06JJ5055 ) and the Science Foundation of University of South China (No. 2008XQD01 ). The authors acknowledge and express appreciation to Rhona Kelly, Fran E. Kovach, and Carol Gordon for editing the manuscript.

机构署名：

本校为通讯机构

院系归属：

中医学院

药学院

摘要：

Objective: To investigate the effect of static pressure on cholesterol accumulation in vascular smooth muscle cells (VSMCs) and its mechanism. Methods: Rat-derived VSMC cell line A10 treated with 50. mg/L ox-LDL and different static pressures (0, 60, 90, 120, 150, 180. mm. Hg) in a custom-made pressure incubator for 48. h. Intracellular lipid droplets and lipid levels were assayed by oil red O staining and HPLC; The mRNA levels of caveolin-1 and ABCA1, the protein levels of caveolin-1 SREBP-1 and mature SREBP-1 were respectively detected by RT-...

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Static pressure accelerates ox-LDL-induced cholesterol accumulation via SREBP-1-mediated caveolin-1 downregulation in cultured vascular smooth muscle cells

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