Use of a Systematic Pharmacological Methodology to Explore the Mechanism of Shengmai Powder in Treating Diabetic Cardiomyopathy

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成果类型：

期刊论文

作者：

Zhang, Shi-ying;Yang, Kai-lin;Long, Zhi-yong;Li, Wei-qing*;Huang, Hui-yong*

通讯作者：

Li, Wei-qing;Huang, Hui-yong

作者机构：

[Zhang, Shi-ying; Li, Wei-qing] Shenzhen Luohu Peoples Hosp, Dept Tradit Chinese Med, Shenzhen, Guangdong, Peoples R China.

[Zhang, Shi-ying; Huang, Hui-yong] Hunan Univ Chinese Med, Changsha, Hunan, Peoples R China.

[Zhang, Shi-ying; Li, Wei-qing] Shenzhen Univ, Dept Tradit Chinese Med, Affiliated Hosp 3, Shenzhen, Guangdong, Peoples R China.

[Zhang, Shi-ying; Li, Wei-qing] Luohu Peoples Hosp, Dept Tradit Chinese Med, Shenzhen Luohu Hosp Grp, Shenzhen, Guangdong, Peoples R China.

[Yang, Kai-lin] Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiac Surg, Beijing, Peoples R China.

通讯机构：

[Li, Wei-qing] S

[Huang, Hui-yong] H

[Li, Wei-qing] L

Shenzhen Luohu Peoples Hosp, Dept Tradit Chinese Med, Shenzhen, Guangdong, Peoples R China.

Hunan Univ Chinese Med, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Diabetic Cardiomyopathies;Herbal Medicine;Medicine, Chinese Traditional

期刊：

Medical Science Monitor

ISSN：

1643-3750

年：

2020

卷：

页码：

e919029

DOI：

10.12659/MSM.919029

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81603512, 81874429]; postgraduate scientific research innovation project of Hunan Province of China [CX20190536, CX20190591, CX2018B465, CX2017B428]; Natural Science Foundation of Hunan Province of ChinaNatural Science Foundation of Hunan Province [2018JJ2289]; Innovation project for graduate students of Hunan University of Chinese Medicine [2018CX05, 2018CX25]; postgraduate scientific research innovation project of Guangdong Yifang Pharmaceutical Co., Ltd. [yf201708]; Digital Chinese medicine innovation research platform project [49021001003005]

机构署名：

本校为通讯机构

摘要：

Background: Cardiovascular complications, such as diabetic cardiomyopathy (DCM), are the leading cause of death in diabetic patients. Shengmai Powder (SMP) was found to have cardioprotective effects. Material/Methods: Based on the systematic pharmacological methodology, this research determined the genes of DCM and the known targets of SMP, predicted potential compounds and targets of SMP, constructed networks for DCM and SMP, and performed network analysis. Results: Five network were constructed: (1) the DCM gene PPI network; (2) the Compound-...

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Use of a Systematic Pharmacological Methodology to Explore the Mechanism of Shengmai Powder in Treating Diabetic Cardiomyopathy

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