Curcumin nicotinate decreases serum LDL cholesterol through LDL receptor-mediated mechanism

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Caiping;Xiang, Debiao;Zhao, Qian;Jiang, Susu;Wang, Chuyao;...

作者机构：

[Wang, Chuyao; Yuan, Yulin; Zhao, Qian; Jiang, Susu; Yang, Huixian; Long, Shiyin; Zhang, Caiping] Univ South China, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang, Hunan, Peoples R China.

[Wen, Hongyan; Liao, Duanfang; Xiang, Debiao; Huang, Ying; Tuo, Qinhui; Zeng, Yaling] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, Changsha, Peoples R China.

[Huang, Zhixin; Liu, Xuanyou; Liu, Zhenguo; Hao, Hong; Zhang, Caiping] Univ Missouri, Ctr Precis Med, Dept Med,Sch Med, Div Cardiovasc Med, Columbia, MO USA.

[Xiang, Debiao] Third Hosp Changsha, Dept Pharm, Changsha, Peoples R China.

[Liu, Zhenguo] Univ Missouri, Sch Med, Dept Med, Div Cardiovasc Med, 1 Hosp Dr, CE344, Columbia, MO 65211 USA.

语种：

英文

关键词：

Curcumin nicotinate;Hyperlipidemia;Low-density lipoprotein receptor;PCSK9;Rosuvastatin

期刊：

European Journal of Pharmacology

ISSN：

0014-2999

年：

2022

卷：

931

页码：

175195

DOI：

10.1016/j.ejphar.2022.175195

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Curcumin nicotinate (Curtn) is a synthesized ester derivative of curcumin and niacin. Our previous study has shown that Curtn lowers serum low-density lipoprotein cholesterol (LDL-C) levels in apoE(-/-) mice and promotes LDL-C uptake into HepG2 cells in vitro. The present study was to test the hypothesis that Curtn decreases serum LDL-C levels through decreased expression of pro-protein convertase subtilisin/kexin type 9 (PCSK9) and subsequent increase in LDL receptor expression. Male Wistar rats on high-fat diet (HFD) were treated with Curtn or rosuvastatin. Curtn or rosuvastatin treatment si...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Curcumin nicotinate decreases serum LDL cholesterol through LDL receptor-mediated mechanism

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问