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Chishao - Fuzi herbal pair restore the macrophage M1/M2 balance in acute-on-chronic liver failure

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成果类型:
期刊论文
作者:
Tan, Nianhua*;Jian, Gonghui;Peng, Jie;Tian, Xuefei*;Chen, Bin*
通讯作者:
Tan, Nianhua;Tian, Xuefei;Chen, Bin
作者机构:
[Tian, Xuefei; Tan, Nianhua; Jian, Gonghui] College of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, 410208, Hunan Province, China
[Tan, Nianhua] Department of Hepatology, The First Hospital of Hunan University of Chinese Medicine, Changsha, 410007, Hunan Province, China. Electronic address: l00342@hnucm.edu.cn
[Peng, Jie] Department of Hepatology, The First Hospital of Hunan University of Chinese Medicine, Changsha, 410007, Hunan Province, China
[Tian, Xuefei] Hunan Province University Key Laboratory of Oncology of Traditional Chinese Medicine Hunan University of Chinese Medicine, Changsha, 410208, Hunan, China
[Tian, Xuefei] Key Laboratory of Traditional Chinese Medicine for Mechanism of Tumor Prevention &Treatment, Hunan University of Chinese Medicine, Changsha, 410208, Hunan, China. Electronic address: 003640@hnucm.edu.cn
通讯机构:
[Tan, Nianhua; Chen, Bin] D
[Tian, Xuefei] K
Department of Hepatology, The First Hospital of Hunan University of Chinese Medicine, Changsha, 410007, Hunan Province, China. Electronic address:
Key Laboratory of Traditional Chinese Medicine for Mechanism of Tumor Prevention &Treatment, Hunan University of Chinese Medicine, Changsha, 410208, Hunan, China. Electronic address:
Department of Hepatology, The First Hospital of Hunan University of Chinese Medicine, Changsha, 410007, Hunan Province, China. Electronic address:
语种:
英文
关键词:
ACLF;Chishao - Fuzi herbal pair;Immune reconstitution;Macrophage polarization
期刊:
Journal of Ethnopharmacology
ISSN:
0378-8741
年:
2024
卷:
328
页码:
118010
基金类别:
Supported by the Hunan Provincial Natural Science Foundation of China, No. 2023JJ40487 and 2020JJ4475; China Postdoctoral Science Foundation, NO. 2022M721127; the Hunan Administration of Traditional Chinese Medicine, NO. B2023009 and C2022005. Scientific Research Project of Education Department of Hunan Province, No. 22B0392. Hunan University of Chinese Medicine School Level Scientific Research Project, No. 2022XJZKC009. CRediT authorship contribution statement Nianhua Tan: Writing – review & editing, Writing – original draft, Project administration, Data curation. Gonghui Jian: Writing – review & editing, Writing – original draft. Jie Peng: Resources, Formal analysis. Xuefei Tian: Supervision, Methodology, acquisition. Bin Chen: Writing – review & editing, Resources, Project administration, acquisition.
机构署名:
本校为第一且通讯机构
摘要:
ETHNOPHARMACOLOGICAL RELEVANCE: Traditional herbal pair Paeoniae Radix Rubra (roots of Paeonia lactiflora Pall., Chishao in Chinese) and Aconiti Lateralis Radix Praeparata (lateral roots of Aconitum carmichaelii Debeaux, Fuzi in Chinese) are widely used for the treatment of liver diseases, demonstrating clinical efficacy against acute-on-chronic liver failure (ACLF). As the core drug pair representing the "clearing method" and "warming method" in traditional Chinese medicine (TCM), they align with the TCM syndromic characteristics of ACLF, char...

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