期刊论文

Effect of Maxin Shigan Decoction and its Alteration on Mice T - cell Subpopulation Exposured to Influenza Virus A

中文

实用预防医学

1006-3110

2007

14

2

278-280

10.3969/j.issn.1006-3110.2007.02.007

湖南省自然科学基金资助项目（06JJ20055）；

本校为第一机构

目的 研究麻杏石甘汤及其加味对A型流感病毒感染小鼠T细胞亚群的影响.方法 用甲型流感病毒鼠肺适应株经鼻腔接种小鼠,建立感染模型.实验设10倍麻杏石甘汤组、5倍麻杏石甘汤组、感染模型组、正常对照组.正常对照组、感染模型组灌胃给生理盐水,其它各组灌胃给相应浓度的药物,1次/d,0.4ml/次,连续8d.最后一次给药后禁水、禁食8h,取标本进行T细胞亚群百分率的检测.结果 10倍麻杏石甘汤加味方组CD3+、CD4+ T细胞亚群百分率、CD4+/CD8+比值显著高于感染模型组(P＜0.05),CD8+ T细胞亚群百分率显著低于感染模型组(P＜0.05).10倍麻杏石甘汤组、5倍麻杏石甘汤加味方组CD8+ T细胞亚群百分率显著低于感染模型...

Objective To investigate the effect of maxin shigan decoction（MSD） and its alteration on mice T- cell subpopulation exposed to influenza virus A. Methods The models were established by inoculating with the influenza virus A fitted to lung via mice nose in mice and then divided into 10 times of MSD, 5 times of MSD, infected model and normal control groups. The normal salt solution was filled up in the control and infected groups and the drug MSD in relevant concentration in the other 2 groups, 1 time per day, each time with 0.4ml, and lasted f...