期刊论文

Effect of Acupuncture on Hyperplasy of Restenosis of Vascular Smooth Muscle and Gene Expression of c-myc and c-foc

中文

实用预防医学

1006-3110

2010

17

3

421-424

10.3969/j.issn.1006-3110.2010.03.002

国家自然科学基金资助项目（30371809） 湖南省教育厅资助项目（08C624）

本校为第一机构

目的 探讨针刺对家兔实验性动脉血管平滑肌细胞c-myc及c-foc基因表达的影响. 方法 家兔随机分为正常对照组(8只),再狭窄组(24只).再狭窄组应用PTCA球囊导管对实验兔行双侧髂动脉内膜剥脱以建立动脉粥样硬化模型,术后 月髂动脉造影示50%以上狭窄者再行PTCA球囊扩张术,以建立再狭窄模型成功后,然后将造模动物随机分成模型组、针刺组、普罗布考组,每组8只.自术前 2d～术后14 d为 疗程,针刺内关(双)、厥阴俞(双)、心俞(双)、膻中、足三里(双)等穴.标本石蜡切片,免疫组化,DAB显色,苏木素复染.观察各组血管平滑肌细胞c-myc、c-foc基因表达. 结果 模型组平滑肌细胞c-myc及c-foc基因表达明显高于正常组(...

Objective To explore the effect of acupuncture on treating vascular smooth muscle cell and gene expression of c-myc and c-foc in rabbits. Methods The rabbits were randomly divided into normal control group （n=8） and re-stricture group （n=24）. To establish atherosclerosis model applying PTCA sacculus proprius to denude arteria iliaca inner membrane two sides in re-stricture group. One month after operation,PTCA sacculus proprius dilatation was made if arteria iliaca opacification indicated that there were artery stricture above 50 percent,af...