期刊论文

中文

实用预防医学

1006-3110

2013

20

2

222-223

10.3969/j.issn.1006-3110.2013.02.034

湖南省自然科学基金项目（10JJ3054） 湖南省中医药科研计划项目（2009023） 湖南省教育厅科学研究项目（09B074）

本校为第一机构

目的 研究护心康对兔动脉粥样硬化防治的作用机制.方法 采用高脂喂饲复制兔动脉粥样硬化模型,将护心康分为低、中、高剂量3个不同剂量组进行干预治疗,检测给药后动脉管壁TLR4中的变化.结果 护心康中、高剂量均有较好的降低兔动脉管壁TLR4的作用,高剂量作用优于低剂量,差异有统计学意义(P＜0.05).结论 护心康具有降低动脉管壁TLR4的功效.

Objective To explore the mechanism of atherosclerosis （AS） prevention and treatment by Huxinkang in rabbits. Methods 90 male Chinese white rabbits were randomly divided into 5 groups： normal group, model group, Huxinkang low, middle and high dose group. The rabbits in all the groups except for the normal group were fed with high cholesterol diet for 63 days. From the 30th day after the finish of the modeling, the rabbits in the Huxinkang low, middle and high dose group were respectively orally administered with Huxinkang at dcse of 0.27, 0.5...