期刊论文

Effect of Huxinkang on serum concentration of NOS and NO in rabbits with atherosclerosis

中文

实用预防医学

1006-3110

2016

23

1

117-119

10.3969/j.issn.1006-3110.2016.01.037

国家自然科学基金项目（81473615） 湖南省自然科学基金项目（2015JJ2107）

本校为第一机构

目的 研究护心康对动脉粥样硬化兔血清NOS、NO浓度的影响. 方法 将家兔随机分为正常对照组6只,模型组、辛伐他汀组及护心康组各10只,除正常对照组普通饲料喂养外,其他组以高脂饲料喂养,建立动脉粥样硬化兔模型.12周造模成功后药物干预四周.16周后检测血脂、ELISA法检测血清NO及NOS浓度. 结果 模型组家兔血清TC、LDL-C明显高于正常对照组(P＜0.05);护心康组血清TC和LDL-C低于模型组(P＜0.05);辛伐他汀组家兔血清HDL-C低于模型组(P＜0.05).与正常对照组相比,其他三组家兔血清NOS、NO浓度降低(P＜0.05),辛伐他汀组与护心康组的家兔血清NOS、NO水平均高于模型组(P＜0.05),但两组之间差异无统计学意义...

Objective To study the effect of Huxinkang on serum concentration of NOS and NO in rabbits with atherosclero-sis. Methods Domestic rabbits were randomly divided into normal control group （ n = 6）, model control group （ n = 10）,simvastatin group （ n = 10） and Huxinkang group （ n = 10）. The rabbits in the normal control group was given normal diet,while those in the other three groups were fed with high fat diet for 12 weaks to establish rabbit models of atherosclerosis. Thena 4 - week drug intervention was conducted. Finally, blood lipid...