期刊论文

中文

食品与药品

1672-979X

2013

15

6

404-406

重大专项课题(2013ZX09402202)；

本校为第一机构

目的 探讨一种催乳中药组方的催乳效果,研究其作用机制.方法 取产仔时间前后相差不超过24 h的50只母鼠,按母鼠体重随机分为正常组、模型组、催乳药物高、低剂量组和阳性对照组,每组10只母鼠.自分娩第2日起每天上午腹腔注射左旋多巴2 mg/kg,连续注射7d.于造模当日开始,每日下午给药,正常组蒸馏水灌胃,每日1次,连续给药14d.从给药第2日开始,每日测定母鼠泌乳量,并于给药14d后,处死动物,酶联免疫吸附测定法(ELISA法)检测血清泌乳素(PRL)和下丘脑5-羟色胺(5-HT)水平,同时取乳腺***固定,并进行病理形态学观察.结果 造模后正常组单次泌乳量和总泌乳量均显著高于模型组,表明产后缺乳大鼠造模成功....

Objective To investigate the effects of lactagogue traditional Chinese medicine combination on rats with postpartum hypogalactia,as well as the mechanism of action.Methods 50 female rats with the difference of childbirth time not more than 24 h were divided randomly into 5 groups according to the weight：normal group,model group,high dose galactogogue group,low dose galactogogue group and positive control group,10 rats per group.From the next day of childbirth,the rats were injected intraperitoneally levodopa 2 mg/kg,once daily in the morning,c...