Screening for Active Compounds of Acorus calamus against SARS-CoV-2 Viral Protease and Mechanism Prediction

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Huang, Yuting;Li, Zhaoxing;Ma, Yuan;Wu, Qianqian;Kong, Jianping;...

通讯作者：

Li, Shunxiang;Li, J

作者机构：

[Huang, Yuting; Zhao, Lijuan; Ma, Yuan; Li, Juan; Li, Shunxiang] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Peoples R China.

[Kong, Jianping; Li, Zhaoxing; Wu, Qianqian] China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Peoples R China.

[Li, Zhaoxing] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Peoples R China.

[Li, Zhaoxing] China Pharmaceut Univ, Chongqing Innovat Inst, Chongqing 401135, Peoples R China.

[Li, Juan; Li, Shunxiang] Hunan Engn Technol Res Ctr Bioact Subst Discovery, Changsha 410208, Peoples R China.

通讯机构：

[Li, SX; Li, J ] H

Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Peoples R China.

Hunan Engn Technol Res Ctr Bioact Subst Discovery, Changsha 410208, Peoples R China.

Hunan Prov Sino US Int Joint Res Ctr Therapeut Dru, Changsha 410208, Peoples R China.

语种：

英文

关键词：

coronaviruses;Acorus calamus;SARS-CoV Mpro;SARS-CoV PLpro;small molecule inhibitors

期刊：

Pharmaceuticals

ISSN：

1424-8247

年：

2024

卷：

期：

页码：

325-

DOI：

10.3390/ph17030325

基金类别：

This research was funded by the National Natural Science Foundation of China (81903783), a research project of the China Medical Association of Minorities (2023MY051-22), the Department of Science and Technology of Hunan Province (No. 2023SK2048), a research and innovative project for graduate students at Hunan University of Chinese Medicine (2023CX148) and the Key Discipline Project on Chinese Pharmacology of Hunan University of Chinese Medicine (202302).

机构署名：

本校为第一且通讯机构

院系归属：

药学院

摘要：

COVID-19, caused by SARS-CoV-2, has emerged as the most destructive emerging infectious disease of the 21st century. Vaccination is an effective method to combat viral diseases. However, due to the constant mutation of the virus, new variants may weaken the efficacy of vaccines. In the current field of new coronavirus research, viral protease inhibitors have emerged as a highly regarded therapeutic strategy. Nevertheless, existing viral protease inhibitors do not fully meet the therapeutic needs. Therefore, this paper turned to traditional Chinese medicine to explore new active compounds. This...

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Screening for Active Compounds of Acorus calamus against SARS-CoV-2 Viral Protease and Mechanism Prediction

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