会议论文

The Effects of Jin Kui Shen Qi Pill on LEP in Rats with Experimental Type Ⅱ Diabetes

中文

2012

201-204

中华中医药学会方剂学分会第十二次学术年会

中华中医药学会方剂学分会第十二次学术年会论文集

2012-08-01

太原

中华中医药学会

本校为第一机构

目的: 探讨金匮肾气丸对2型糖尿病胰岛素抵抗大鼠血清瘦素的影响. 方法: 40只SD大鼠采用高脂高糖饲料喂养3周,小剂量链脲佐菌素(STZ)腹腔注射诱导2型糖尿病胰岛素抵抗大鼠,随机分为模型组、二甲双胍组、肾气丸高剂量组、肾气丸低剂量组(每组10只).另设正常组10只,饲以普通饲料.给药6周后处死大鼠,末次给药后禁食12h,检测空腹血糖(FBG)、血清胰岛素(FINS)、血清瘦素(LEP),计算胰岛素抵抗指数(HOMA-IR). 结果: 二甲双胍组、肾气丸高、低剂量组FBG、FINS水平较模型组均明显降低(P＜0.05,P＜0.01),LEP、HOMA-IR均明显降低(P＜0.01).与正常组比较,模型组和肾气丸低剂量血清瘦素水平明显升高...

　　objective:To study the effects of Jin Kui Shen Qi Pill on LEP in Rats with Experimental Type ⅡDiabetes.Methods: 40 SD rats were randomly divided into control group, metformin group, Shen Qi Pill high dose group, Shen Qi Pill low doses group (each group of 10 only) after used high fat and sugar feed 3 weeks and small dose Streptozotocin (STZ intraperitoneal injection) induced type 2 diabetes rats with insulin resistance.A normal group of 10 with ordinary feed.The rats were killed in the 6th week, fasting blood-glucose(FBG), fasting insul(Fi...