WNT5A promotes stemness characteristics in nasopharyngeal carcinoma cells leading to metastasis and tumorigenesis

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成果类型：

期刊论文

作者：

Qin, Li;Yin, Yan-Tao;Zheng, Fang-Jing;Peng, Li-Xia;Yang, Chang-Fu;...

通讯作者：

Qian, Chao-Nan

作者机构：

[Qian, Chao-Nan; Zeng, Yi-Xin; Zheng, Fang-Jing; Li, An-Hua; Zou, Ru-Hai; Qin, Li; Liang, Ying-Ying; Kang, Tie-Bang; Li, Xin-Jian; Pei, Xiao-Qing; Bao, Ying-Na; Peng, Li-Xia; Yang, Chang-Fu; Huang, Bi-Jun] Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Guangzhou 510275, Guangdong, Peoples R China.

[Qin, Li] Hunan Univ Chinese Med, Sch Pharm, Hunan Prov Engn Res Ctr Bioact Subst Discovery Tr, Changsha, Hunan, Peoples R China.

[Qin, Li; Yin, Yan-Tao] Univ South China, Inst Pharm & Pharmacol, Div Pharmacoprote, Hengyang, Hunan, Peoples R China.

[Zheng, Fang-Jing] Fujian Med Univ, Affiliated Hosp, Ningde Municipal Hosp, Dept Radiotherapy, Ningde, Fujian, Peoples R China.

[Li, Xin-Jian] Univ Texas MD Anderson Canc Ctr, Brain Tumor Ctr, Houston, TX 77030 USA.

通讯机构：

[Qian, Chao-Nan] S

Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Guangzhou 510275, Guangdong, Peoples R China.

语种：

英文

关键词：

PKC;WNT5A;metastasis;nasopharyngeal carcinoma;tumorigenesis

期刊：

Oncotarget

ISSN：

1949-2553

年：

2015

卷：

期：

页码：

10239-10252

DOI：

10.18632/oncotarget.3518

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81272340, 81000946, 81172041, 81030043, 81270359, 81472386]; National High Technology Research and Development Program of China (863 Program)National High Technology Research and Development Program of China [2012AA02A501]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Nasopharyngeal carcinoma (NPC) has the highest metastasis rate among head and neck cancers with unclear mechanism. WNT5A belongs to the WNT family of cysteine-rich secreted glycoproteins. Our previous high-throughput gene expression profiling revealed that WNT5A was up-regulated in highly metastatic cells. In the present study, we first confirmed the elevated expression of WNT5A in metastatic NPC tissues at both the mRNA and protein levels. We then found that WNT5A promoted epithelial-mesenchymal transition (EMT) in NPC cells, induced the accumulation of CD24-CD44+ cells and side population, w...

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WNT5A promotes stemness characteristics in nasopharyngeal carcinoma cells leading to metastasis and tumorigenesis

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