期刊论文

Experimental Study of Dahuang Zhechong Pill (DHZC) in Treatment of Liver Fibrosis

中文

中西医结合肝病杂志

1005-0264

1997

007

2

90-92

国家“八五”科技攻关项目(85—919—04—02)

本校为第一机构

目的：研究大黄Ｚｈｅ虫丸预防和治疗肝纤维化的作用。方法：运用牛血清白蛋白致大鼠免疫损伤性肝纤维化模型，观察大Ｚｈｅ黄虫丸对肝组织病理学、肝组织羟脯氨酸（ＨｙＰ）和血清透明质酸（ＨＡ）及肝功能的影响，并设秋水仙碱作对照。结果：大黄Ｚｈｅ虫丸预防和治疗组肝纤维化率分别为７２．７％和７１．４％，而模型组和秋水仙碱组肝纤维化率为９２．３－１００％，尤其是大黄Ｚｈｅ虫丸治疗试验组肝ＨｙＰ含量下降最显著，与模

Objective To study the effect of DHZC on liver fibrosis. Methods Inutmo-injured fibrosis in rate was indued by bovine serum albmin and DHZC was given during and after model production respectively Hepatic collagen contents, pathology of liver and serum hs luronic acid, transeminase were observed using colchicine as control. Results Liver fibrosis rate of DHZC group during and after model prodnction wer 72.67% and 71. 4% respectively, whereas, the untreated and colchicine groups' were 93. 3%-100%. There was a remarkable decrease of hepatic collagen contents of DHZC in after model production gro...