Overexpression of AKR1B10 in nasopharyngeal carcinoma as a potential biomarker

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成果类型：

期刊论文、会议论文

作者：

He, Ying-Chun;Shen, Yi;Cao, Yu;Tang, Fang-Qing;Tian, Dao-Fa;...

通讯作者：

Cao, Deliang;Liao, Duan-Fang

作者机构：

[Zhou, Fang-Liang; He, Ying-Chun; Liao, Duan-Fang; Tian, Dao-Fa; Song, Lan; Lu, Fang-Guo; Lin, Li-Mei; Zhang, Bo; Cao, Deliang; He, Lan; Tao, Huai] Hunan Univ Chinese Med, State Key Lab Chinese Med Powder & Med Innovat Hu, Div Stem Cell Regulat & Applicat, Changsha, Hunan, Peoples R China.

[Shen, Yi; He, Ying-Chun; Cao, Yu; Cao, Deliang; Huang, Chen-Fei] So Illinois Univ, Sch Med, Simmons Canc Inst, Dept Med Microbiol Immunol & Cell Biol, 913 N Rutledge St, Springfield, IL 62794 USA.

[Tang, Fang-Qing] First Peoples Hosp Zhuhai, Zhuhai, Guangdong, Peoples R China.

[Liao, Duan-Fang] Hunan Univ Tradit Chinese Med, Div Stem Cell Regulat & Applicat, 1 Xiangzui Rd, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Cao, Deliang] S

[Liao, Duan-Fang] H

So Illinois Univ, Sch Med, Simmons Canc Inst, Dept Med Microbiol Immunol & Cell Biol, 913 N Rutledge St, Springfield, IL 62794 USA.

Hunan Univ Tradit Chinese Med, Div Stem Cell Regulat & Applicat, 1 Xiangzui Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Aldo-keto reductase 1B10;nasopharyngeal carcinoma;tumor marker,squamous cell carcinoma;nasopharyngeal lesions

期刊：

CANCER BIOMARKERS

ISSN：

1574-0153

年：

2016

卷：

期：

页码：

127-135

会议名称：

2015全国中医药生物化学与分子生物学年会

会议论文集名称：

2015全国中医药生物化学与分子生物学年会论文集

会议时间：

2015-08-01

会议地点：

兰州

会议赞助商：

中国生物化学与分子生物学会

DOI：

10.3233/CBM-150548

基金类别：

This work was supported by National Natural Science Foundation of China (81273988 for YCH, 31371 161 for DFL, and 81272918 and 81472465 for DC) and Hunan Provincial Science and Technology Department of China (2014FJ3021 for YCH).

机构署名：

本校为通讯机构

院系归属：

药学院

摘要：

BACKGROUND: Nasopharyngeal carcinoma (NPC) is one of the most common cancers in Southern China. Aldo-keto reductase 1B10 (AKR1B10) is upregulated in multiple tumors and plays an oncogenic role. OBJECTIVE: To examine the expression of AKR1B10 at mRNA and protein levels in nasopharyngeal tumors and correlate its expression with clinicopathological parameters. METHODS: A tissue microarray, paraffin blocks, and frozen surgical nasopharyngeal samples were procured. Western blot and immunohistochemistry were used to estimate AKR1B10 protein expressio...

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Overexpression of AKR1B10 in nasopharyngeal carcinoma as a potential biomarker

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