期刊论文

Liao, Duan-fang;Tuo, QH

英文

Materials & Design

0264-1275

2023

229

111931

10.1016/j.matdes.2023.111931

Key Research and Development Projects of Hunan Provincial Science and Technology Department [2022SK2011]; Science and Technology Innovation team of Hunan Province; Key Projects of Hunan Provincial Department of Education [CX20210699]; Hunan Provincial Innovation Foundation For Postgraduate [2021CX10]; Graduate Innovation Project of Hunan University of Chinese Medicine [2022JJ40314]; Natural Science Foundation of Hunan Province [2021RC4064]; [20A379]

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Reducing lipid uptake of macrophages and stimulating cholesterol efflux are two necessary steps for atherosclerotic plaque regression. In this study, a compound of curcumin nicotinate (CN) was synthesized from nicotinic acid which can raise raising high-density lipoprotein (HDL) and curcumin which can lower lipid. However, the shortcomings of CN, such as poor water solubility and low bioavailability, limit its clinical application. In this article, a CN loaded biomimetic nanosystem was constructed by using Prussian blue nanoparticles (PB NPs) to improve its solubility, thereby changing its adm...