期刊论文

Study on Homeostatic Effect of Compound Weirekang on Gastric Hemorrhage Model Caused by Heat Evil in Animals

中文

中国中医药信息杂志

1005-5304

2004

11

4

306-307

10.3969/j.issn.1005-5304.2004.04.012

湖南省教育厅科研计划项目（A0066）；

本校为第一机构

目的观察复方胃热康对热盛胃出血小鼠模型的作用,初步探讨复方胃热康的止血作用机理.方法参照有关文献造成热盛胃出血模型,观察药物对小鼠热盛胃出血模型的影响,用断尾法及毛细玻管法分别测定本品对小鼠出血时间(BT)和凝血时间(CT)的影响,以血小板数(Plt)、血红蛋白(Hb)、血浆凝血酶原时间(PT),活化部分凝血活酶时间(APTT)为检测指标,并用平面体视显微镜观察各小鼠腺胃部出血点数.结果与模型组及空白组比较,其余各用药组的BT、CT、Plt、Hb、PT、APTT均有显著性改变(P＜0.05),出血点数也有显著性改变(P＜0.05).结论复方胃热康对热盛胃出血模型有止血作用,其机理与激活内外凝血系统有关.

Objective To observe hemostatic effect of compound Weirekang on gastric hemorrhage model caused by heat and inquire into the principle of hemostatic effect. Methods Applying the bleeding time (BT) test and coagulation time (CT) test to investigate the hemostatic effect, applying the platelet count (Plt), hemoglobin (Hb), prothrombin time (PT), active partial thromboplastin time (APTT) and counting the bleedings of pars pylorica on every mouse. Results Obviously therapeutic effects on gastric hemorrhage model caused by heat were found:The CT and BT were shortened (P