期刊论文

Effect of Dingchuantang on Expression of NGF in Lung and Thymus of Asthmatic Rats

中文

中国中医药信息杂志

1005-5304

2009

16

4

21-22

10.3969/j.issn.1005-5304.2009.04.009

基金项目：湖南省教育厅课题（A0128）

本校为第一机构

目的 探讨定喘汤对哮喘大鼠肺组织及胸腺神经生长因子(NGF)表达的影响.方法 将Wistar大鼠32只随机分为正常对照组、模型组、定喘汤组、必可酮组,每组8只.除正常对照组外,其余各组制备哮喘模型,并分别用药,共1 5 d.采用免疫组织化学方法,观察大鼠肺和胸腺NGF表达的变化.结果 模型组大鼠NGF在肺组织和胸腺表达明显高于正常对照组,而定喘汤组则明显低于模型组.结论 NGF可能参与哮喘的发病过程,定喘汤抑制哮喘大鼠NGF的表达可能是其治疗哮喘的机制之一.

Objective To explore the effect of Dingchuantang on the expression of NGF in the lung and thymus of asthmatic rats. Methods Thirty two Wistar rats were randomly divided into control group, asthmatic group, Dingchuantang group and Beclomethasone group, 8 rats for each group. Asthmatic model was made except the control group. The change of NGF expression in the lung and thymus were observed by means of immunohistochemistry. Results The expression of NGF in the lung and thymus of asthmatic group was much higher than that of control group and that of Dingchuantang group was much lower than that of...